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The results of the Roslin Institute’s Bovine Genome
Mapping Programme (RoBoGen) are now available and collaboration with
interested parties
by way of licence agreement or joint venture and/or technical collaboration
is now sought. (The world-famous Roslin Research Institute is situated
near Edinburgh, Scotland - www.roslin.ac.uk )
In general terms the project
and the results can be summarised as follows:
- A cross-bred herd
of cattle was bred from diverse purebred Holstein and Charolais founders
- Over 500 second generation cross-bred animals were produced
- A panel of markers was assembled with an average interval of 20 cM
- The F0, F1 and second generation cross bred animals were genotyped with
the marker panel.
- Animals were recorded for management, feed intake and immune traits while
growing and for meat quality traits post slaughter
- A QTL analysis of carcase and meat traits identified 122 QTL with chromosome-wide
significance, of which 28 QTL had genome-wide significance.
- Analysis of immune related traits identified 64 QTL with chromosome-wide
significance of which 6 QTL showed genome-wide significance
- Polymorphisms within a candidate gene were found to be associated with
feed intake and fatness traits.
- Further work will be required to fine map and confirm whether the QTL
identified are segregating in other (commercial) cattle populations.
- Information produced in this project provides the starting point to identify
the functional differences in genes underlying the QTL responsible
for variations in traits important for beef production.
A detailed report
on the results from the RoBoGen is available to interested parties subject
to the completion of an appropriate Confidentiality Disclosure
Agreement.
For further information and to express interest in the
opportunity please contact Professor Charlotte Maltin, Science and Innovation
Manager,
Quality
Meat Scotland, email: cmaltin@qmscotland.co.uk
[4 Jan 07]
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